Skip to main content
Denver Broncos quarterback Bo Nix throws the ball as we offer our NFL Week 13 predictions and odds for this week.
Denver Broncos quarterback Bo Nix (10) throws the ball. Photo by Kirby Lee / Imagn Images.

Following the lightest week of the NFL season, we're offering our NFL Week 13 odds and predictions for a full 16-game slate with four games scheduled before Sunday - including three on Thanksgiving Day.

The action starts Thursday at 12:30 p.m. ET with a classic NFC North rivalry between the Chicago Bears and the Detroit Lions. The latter enter this week as the Super Bowl odds favorites and one of two double-digit favorites in Week 13.

The other is the Kansas City Chiefs, who host the Las Vegas Raiders on Friday at 3 p.m. ET. That precedes a busy Sunday slate capped off by the Sunday Night Football odds clash between the San Francisco 49ers and Buffalo Bills at 8:20 p.m. ET (NBC).

The week concludes with the Monday Night Football odds showdown between the Cleveland Browns and the Denver Broncos to wrap up the NFL Week 13 odds.

NFL picks & predictions Week 13

Don't miss the rest of our Week 13 NFL picks. Our NEW NFL player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

NFL odds & predictions for Thursday (Thanksgiving Day)

NFL odds updated live courtesy of our best NFL betting sites. Follow the latest NFL scores for line history and matchup info.

Best Bears vs. Lions odds

Prediction: Jahmyr Gibbs Over 19.5 receiving yards (-110 via bet365) ⭐⭐⭐⭐

Canada's Most Popular Sportsbook

Terms and conditions apply.

Each product featured on our website has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission. 19+. Gambling can be addictive, please play responsibly.

Pick made by Mike Spector.

  • When: Thursday, Nov. 28 - 12:30 p.m. ET
  • Where: Ford Field (Detroit)
  • How to watch: CBS

Best Giants vs. Cowboys odds

Prediction: Malik Nabers Over 53.5 receiving yards (-115 via BetMGM) ⭐⭐⭐⭐

Live Betting Odds

Terms and conditions apply.

Each product featured on our website has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission. 19+. Gambling can be addictive, please play responsibly.

Pick made by Mike Spector.

  • When: Thursday, Nov. 28 - 4:30 p.m. ET
  • Where: AT&T Stadium (Arlington, Texas)
  • How to watch: FOX

Best Dolphins vs. Packers odds

Prediction: Packers -3 (-120 via BetMGM) vs. Dolphins ⭐⭐⭐

Pick made by Mike Spector.

  • When: Thursday, Nov. 28 - 8:20 p.m. ET
  • Where: Lambeau Field (Green Bay, Wis.)
  • How to watch: NBC

NFL odds & predictions for Black Friday

Best Raiders vs. Chiefs odds

  • When: Friday, Nov. 29 - 3 p.m. ET
  • Where: GEHA Field at Arrowhead Stadium (Kansas City, Mo.)
  • How to watch: Prime Video

NFL odds & predictions for Sunday

Best Chargers vs. Falcons odds

  • When: Sunday, Dec. 1 - 1 p.m. ET
  • Where: Mercedes-Benz Stadium (Atlanta)
  • How to watch: CBS

Best Colts vs. Patriots odds

  • When: Sunday, Dec. 1 - 1 p.m. ET
  • Where: Gillette Stadium (Foxborough, Mass.)
  • How to watch: CBS

Best Titans vs. Commanders odds

  • When: Sunday, Dec. 1 - 1 p.m. ET
  • Where: Northwest Stadium (Landover, Md.)
  • How to watch: CBS

Best Cardinals vs. Vikings odds

  • When: Sunday, Dec. 1 - 1 p.m. ET
  • Where: U.S. Bank Stadium (Minneapolis)
  • How to watch: FOX

Best Texans vs. Jaguars odds

  • When: Sunday, Dec. 1 - 1 p.m. ET
  • Where: EverBank Stadium (Jacksonville, Fla.)
  • How to watch: FOX

Best Seahawks vs. Jets odds

  • When: Sunday, Dec. 1 - 1 p.m. ET
  • Where: MetLife Stadium (East Rutherford, N.J.)
  • How to watch: FOX

Best Steelers vs. Bengals odds

  • When: Sunday, Dec. 1 - 1 p.m. ET
  • Where: Paycor Stadium (Cincinnati, Ohio)
  • How to watch: CBS

Best Buccaneers vs. Panthers odds

  • When: Sunday, Dec. 1 - 4:05 p.m. ET
  • Where: Bank of America Stadium (Charlotte, N.C.)
  • How to watch: FOX

Best Rams vs. Saints odds

  • When: Sunday, Dec. 1 - 4:05 p.m. ET
  • Where: Caesars Superdome (New Orleans)
  • How to watch: FOX

Best Eagles vs. Ravens odds

  • When: Sunday, Dec. 1 - 4:25 p.m. ET
  • Where: M&T Bank Stadium (Baltimore)
  • How to watch: CBS

NFL odds & predictions for Sunday Night Football

Best 49ers vs. Bills odds

  • When: Sunday, Dec. 1 - 8:20 p.m. ET
  • Where: Highmark Stadium (Orchard Park, N.Y.)
  • How to watch: NBC

NFL odds & predictions for Monday Night Football

Best Browns vs. Broncos odds

  • When: Monday, Dec. 2 - 8:15 p.m. ET
  • Where: Empower Field at Mile High (Denver)
  • How to watch: ESPN

NFL picks roundup: Week 13

NFL betting odds pages

Here are our best NFL betting sites:

(21+. Gambling Problem? Call 1-800-GAMBLER)
* Bonuses not applicable in Ontario.

Not intended for use in MA.
Each betting site featured on SBR has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.

Related pages