49ers vs. Buccaneers Player Prop Bet Odds & Touchdown Picks: Can McCaffrey Make Immediate Impact?
Christian McCaffrey couldn’t be returning at a better time for the 4-4 San Francisco 49ers, who hope to start a second-half surge Sunday in Tampa against the struggling Buccaneers (1 p.m. ET, FOX.). The Niners enter sitting fifth in the Super Bowl odds, while quarterback Brock Purdy is a long shot in the NFL MVP odds.
Will CMC make an immediate impact during his regular-season debut? How will the star running back’s return affect the rest of the 49ers' offense? And Can Baker Mayfield and the 4-5 Bucs spoil his day with a significant game of their own?
We answer those questions and more with our 49ers vs Buccaneers player prop bet odds and touchdown picks based prices from the best NFL prop betting sites.
49ers vs. Buccaneers NFL player prop bets: Sunday
Odds as of Thursday and subject to change.
- Deebo Samuel Over 1.5 touchdowns (+1100 via FanDuel) ⭐⭐⭐
- Baker Mayfield Over 0.5 interceptions (-139 via Caesars) ⭐⭐⭐⭐⭐
- Cade Otton anytime touchdown (+180 via FanDuel) ⭐⭐⭐⭐
NFL picks made Thursday; odds subject to change. Our NEW NFL player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!
49ers vs. Buccaneers touchdown pick
Deebo Samuel Over 1.5 touchdowns (+1100) ⭐⭐⭐
If the 49ers are going to score many touchdowns in this game, that damage will most likely come through the air. Currently, 17 of the 19 touchdowns Tampa Bay has surrendered over the past five weeks have been through the pass, including 12 in the past three weeks alone.
With Brandon Aiyuk out for the year and head coach Kyle Shanahan uncertain about McCaffrey’s conditioning in his season debut, Brock Purdy should be looking Samuel’s way a lot. San Francisco has been trending in that direction recently, with Samuel posting 173 yards and two touchdowns in his last two full games.
The odds on this prop are a great example of how comparing lines with SBR's NFL player prop odds tool can really pay off. FanDuel’s +1100 price on Samuel going Over 1.5 touchdowns is nearly double the return that you’ll find at DraftKings (+600) and Caesars (+650).
Best odds: +1100 via FanDuel | Implied probability: 8.3%
Best 49ers vs. Buccaneers prop bets
Baker Mayfield Over 0.5 interceptions (-139) ⭐⭐⭐⭐⭐
The absence of Mike Evans and Chris Godwin hasn’t hurt Baker Mayfield’s passing yardage numbers. But that might be impacting another area: interceptions. Seven of Mayfield’s nine interceptions this season have come since he lost his favorite two targets a month ago.
I expect that trend to continue against a 49ers defense looking to record multiple interceptions for a fourth straight game, which San Francisco hasn’t done in a single season since 2014. Nick Bosa and the 49ers’ pass rush can force Mayfield to throw the ball quicker than he’d like, especially if the Bucs are forced to resort heavily to the pass while trailing in the second half.
I’d still play this prop at the -155 price DraftKings and BetMGM are offering. But the -139 odds you can get at Caesars lead to even better value for your NFL Week 10 predictions.
Best odds: -139 via Caesars | Implied probability: 58.2%
Caesars is a 21+ product
Cade Otton anytime touchdown (+180) ⭐⭐⭐⭐
The other huge impact of the injuries to Evans and Godwin has been to Bucs tight end Cade Otton and his workload. He's caught 25 passes for 258 yards and three touchdowns over Tampa's last three games, eclipsing 75 receiving yards in each of those contests.
Meanwhile, San Francisco’s defense has been vulnerable to tight ends over the past month, allowing 60, 76, and 83 yards to the position before giving up just 23 yards against Dallas last week.
FanDuel (+180) and Caesars (+170) are your leading options among our best NFL betting sites for playing this prop. I wouldn’t go with DraftKings (+140).
Best odds: +180 via FanDuel | Implied probability: 35.7%
49ers vs. Buccaneers game info
- When: Sunday, Nov. 10
- Kickoff: 1 p.m. ET
- Where: Raymond James Stadium, Tampa, FL
- How to watch: FOX
- Weather: 86 degrees, 20% chance of precipitation, 10 mph winds E
- Favorite: 49ers -6 (-110 via Caesars)
NFL betting odds pages
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