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Stanford vs. Duke Prediction, Odds & Preview Today: Best Picks for Feb. 15

Mike Spector

Last Updated: February 15, 2025 11:20 AM EST • 3 min 11 sec read.

Stanford vs. Duke Prediction
Pictured: Stanford Cardinal forward Maxime Raynaud in action against the Georgia Tech Yellow Jackets. Photo by Brett Davis / Imagn.

The Duke Blue Devils host a school from California for the second straight game as they welcome the Stanford Cardinal to Cameron Indoor Stadium this afternoon.

Our Stanford vs. Duke prediction and odds suggest the Cardinal will stay within this big number despite the Blue Devils’ dominance in ACC play thus far. Duke is coming off a workmanlike 78-57 victory over Cal on Wednesday, so it's no surprise to see it as 19.5-point favorite ahead of this game.

Tipoff from Durham is set for 4 p.m. ET, airing on ABC/ESPN+.

Stanford vs. Duke predictions today

College basketball picks based on the odds from our best March Madness betting sites. 

  • Against the spread pick: Stanford +20.5 (-115 via FanDuel) vs. Duke ⭐⭐⭐
  • My best pick: Maxime Raynaud Over 1.5 made 3-pointers (+110 via FanDuel) ⭐⭐⭐

Stanford vs. Duke ATS prediction

Stanford to cover the spread: +20.5 ⭐⭐⭐

This is likely to be a contrarian play as Duke is a dominant 13-1 in ACC play this year, and it's favored to win the rest of its seven games, including five by double digits, per KenPom.

Duke failed to cover as 23.5-point home favorites against Cal, despite building a 26-point lead midway through the second half. Now the team is 3-6 against the spread in its last nine games as at least an 18-point favorite.

This game should play out similarly to the Cal contest in which Duke exerted its dominance early. However, the Blue Devils' schedule will prevent it from going full throttle for the entire 40 minutes.

While Stanford doesn't play again until next Saturday, Duke faces a quick turnaround with a road trip to Virginia on tap Monday. Thus, don't be surprised if Blue Devils head coach Jon Scheyer goes to the bench more to rest his starters’ legs.

This is a three-star play, as the Cardinal shoot an ACC-best 85.3% from the free-throw line in league play. Their turnover rate (15.6%) also ranks in the top-60 nationally, which should help navigate a tough road environment with the Cameron Crazies in full force.  

The best value for Stanford backers is found at FanDuel. Despite needing to pay up slightly in juice to back the Cardinal at -115 odds, FanDuel is alone among our best sports betting sites while offering a spread of +20.5 compared to +19.5 at all its other competitors.

Best odds: -115 via FanDuel | Implied probability: 53.49%

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Best Stanford vs. Duke pick

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Maxime Reynaud to make Over 1.5 3-pointers ⭐⭐⭐

Though this game may not be the most competitive, it'll be worth the price of admission alone to see Stanford’s Maxime Reynaud do battle with Duke’s Cooper Flagg.

Clemson exposed Duke’s usually impenetrable interior defense, which ranks second nationally (42.6% allowed). The Tigers shot 63.4% inside the arc in last Saturday’s upset win. 

However, Duke’s defense returned to form against Cal, holding the Golden Bears to 38.2% shooting from 2-point range.

That has me believing Stanford will utilize Reynaud’s mobility to stretch the floor and pull Duke’s bigs away from the basket.

Reynaud is in a shooting slump currently, as he's made just one of his last 15 3-point attempts over the last three games. 

However, this is still a confident three-star play, as Reynaud has tallied six-plus 3-point attempts in six of his last eight games. I expect positive shooting regression from a player who has made multiple 3-pointers in 13 games this season. 

FanDuel offers +290 odds for Raynaud to make three-plus 3-pointers, but backing him at plus-money odds to make at least two from beyond the arc is plenty enough value.

Best odds: +110 via FanDuel | Implied probability: 47.62%

Live Stanford vs. Duke odds odds

See all of this week's college basketball odds and NCAAB scores.

Stanford vs. Duke odds opening odds

  • Spread: Stanford +20.5 (-115 via BetMGM) | Duke -20.5 (-115 via BetMGM)
  • Over/Under: Over 141.5 (-110 via BetMGM) | Under 141.5 (-110 via BetMGM)
  • Moneyline: Stanford +1400 via BetMGM | Duke -5000 via BetMGM

Stanford vs. Duke odds game info

  • When: Saturday, Feb. 15
  • Tipoff: 4 p.m. ET
  • Where: Cameron Indoor Stadium (Durham, N.C.)
  • How to watch: ABC/ESPN+
  • Favorite: Duke -19.5 (-110 via BetMGM)

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Written By:
Mike Spector
Mike started in the sports writing industry in July 2019, and gained a lot of followers in his first year after finishing with the No. 2 overall record in an annual NFL betting competition, which made picks against the spread, and from an Over/Under and moneyline perspective. Mike is an avid fan of the NFL, MLB, tennis, and all college sports. In his opinion, March Madness is the best sporting event there is, and he's especially euphoric starting with conference tournament time in college basketball. Mike's a big advocate of "fading the public" and making plays that are contrarian, constantly citing that "there are reasons why they have those big shiny buildings in Las Vegas." When making wagers, Mike always scours the best odds at all of the major sports betting sites, where he mostly sifts through DraftKings, FanDuel, BetMGM, and bet365. He's tried several others and is of the firm belief that bettors should not just stick to one sportsbook, as there is always likely better value to be had with the same wager. In addition, while Mike received his undergraduate degree from Villanova University, he has no issue betting against the Wildcats when it comes to college basketball wagering, and suggests other bettors should always put their “head” before their “hearts.”