SMU vs. Clemson Prediction, Odds & Score Picks: ACC Quarterfinals Best Bets

Though the ACC isn’t as good this year as college basketball fans typically expect, the Clemson Tigers are an example of a team that is more than capable of a run in March.
Our SMU vs. Clemson prediction, odds, and expert picks for the ACC quarterfinals don’t envision the Mustangs matching up well against a Tigers group that has been running teams off the floor consistently in recent weeks.
SMU and Clemson face off in the quarterfinals of the ACC tournament at Spectrum Center in Charlotte, N.C, Thursday at 9:30 p.m. ET (ESPN2).
💰 SMU vs. Clemson predictions, expert picks & best bets: ACC Quarterfinals
Here are my best SMU vs. Clemson predictions, expert picks, and best bets today for the ACC quarterfinals with my pick confidence based on a 1-to-5-star scale. Be sure to check out the rest of our college basketball picks along with our guide on how to bet on college basketball.
- Against the spread pick: Clemson -6.5 (-110 via FanDuel vs. SMU ⭐⭐⭐⭐
- My best Over/Under pick: Over 144.5 (-110 via BetMGM) ⭐⭐⭐⭐
- Exact score prediction: Clemson 78, SMU 69 (+23000 via FanDuel)
👉 Check out our latest March Madness projections with our SBR Bracketology ahead of the NCAA Tournament!
🏀 SMU vs. Clemson ATS prediction & best Over/Under pick
Here's why I'm betting on Clemson to cover the spread (-6.5) while targeting Over 144.5 as my best Over/Under pick for tonight's matchup:
✅ Clemson to cover the spread (-6.5) ⭐⭐⭐⭐⭐
Clemson beat SMU 79-69 on Feb. 22 in Dallas, an impressive road outing amid the Tigers’ current eight-game winning streak. Clemson kicked off this stretch on Feb. 8 with a six-point win over Duke and proceeded to win the next seven subsequent games by nine or more points.
In a down year for the ACC, SMU isn’t even sniffing the March Madness bracket according to most bracketology projections, so a long run in Charlotte is the Mustangs’ only hope. It’s just hard to project it against a Clemson team that has been so dominant of late, ranking fourth in the nation in the Torvik ratings since its win over Duke.
Given that stretch has spanned longer than a month, it’s not some fluke. Clemson is 20-11 against the spread this season.
📊 Best odds: -110 via FanDuel (bet $10 to win $9.09)
🔥 Over 144.5 ⭐⭐⭐⭐
The trends on totals haven’t been strong in either direction with both SMU and Clemson landing rather close to .500 marks on Over/Under results this season. The scoring potency for the Mustangs and Tigers, however, suggests the potential for an affair that exceeds the total in the mid-140s for Thursday,
SMU and Clemson both rank among the top 75 in points per game across Division 1, combining to score an average of 157.9 PPG. The previous meeting between the two teams this season finished with 148 total points.
Given SMU’s situation as a team with a good record but not enough quality wins to garner March Madness odds consideration, I could see desperation leading to lots of late fouling to help push this game to the Over.
📊 Best odds: -110 via BetMGM (bet $10 to win $9.09)
🎯 Expert SMU vs. Clemson score prediction
🔮 Expert score prediction: Clemson 78, SMU 69
Clemson ranks 24th in the nation in scoring defense, allowing only 65.7 points per game to its opponents. Given that SMU scores better than 80 PPG, we like the Mustangs to at least push Clemson slightly relative to its season norms defensively.
But the Tigers’ efficient offense should be able to push against SMU’s 75th-ranked adjusted defensive efficiency in a manner similar to how the previous matchup unfolded.
After seeing a streak of eight straight games with 70 or more points snapped in a slog-it-out win over Virginia Tech in the regular season finale, I look for Clemson to reassert its offensive presence against SMU as it begins its ACC tournament run.
📊 Best odds: +23000 via FanDuel (bet $10 to win $2,300)
📊 Live SMU vs. Clemson odds
Here are the latest odds for SMU vs. Clemson, which update live in real time. You can also check out our NEW college basketball player prop odds tool for the latest college basketball odds on any market across legal sportsbooks in your region.
🔢 SMU vs. Clemson opening odds
Here's a look at the opening odds for SMU vs. Clemson according to SBR’s oddsboard.
- Spread: SMU +5.5 (-102 | Clemson -5.5 (-118)
- Moneyline: SMU +200 | Clemson -250
- Over/Under: Over 144.5 (-110) | Under 144.5 (-110)
🏆 Who will win SMU vs. Clemson?
As of 10 a.m. ET, Clemson is favored by 6.5 points to beat SMU with moneyline odds of -300 at BetMGM, which suggest a 75% win probability for the Tigers. We're predicting a 78-69 win for Clemson as our final score projection.
📺 How to watch SMU vs. Clemson today/tonight
📅 Date: Thursday, March 13
🕗 Time: 9:30 p.m. ET
📍 Location: Spectrum Center (Charlotte, N.C.)
📺 TV: ESPN2
💻 Streaming: ESPN App
❓ SMU vs. Clemson FAQs
Who's favored to win the ACC tournament?
Duke is favored to win the ACC tournament, with current ACC Tournament odds of -330 at FanDuel.
Who is favored to win SMU vs. Clemson?
Clemson is favored to beat SMU with moneyline odds of -300, equating to an implied win probability of 75%.
What are the betting odds for SMU vs. Clemson?
The latest spread is SMU +6.5 (-110) | Clemson -6.5 (-110), with a total of 144.5 points (-110).
What will be the final score of SMU vs. Clemson?
We're predicting a final score of Clemson 78, SMU 69 entering tonight's matchup at Spectrum Center.
What time is SMU vs. Clemson tonight?
Tipoff is scheduled for 9:30 p.m. ET.
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