Final Four Odds & Predictions: Who Will Win Men's NCAA Tournament Championship?
Get ready for one of the best Final Fours of all time this weekend, as all four No. 1 seeds in March Madness battle it out in San Antonio in the 2025 NCAA Tournament semifinals.
Duke and Florida are the favorites to emerge from the Final Four and meet in the men's NCAA championship, but they'll both need to outlast elite opponents on Saturday in arguably the most star-studded semifinals in NCAA Tournament history.
Here's a look at the latest Final Four odds and predictions for every game this weekend:
📊 March Madness odds: Who will win men's NCAA Championship?
The March Madness odds below reflect the best odds from our best sports betting sites and will update in real time. You can also check out our college basketball player prop odds tool for the best March Madness odds across legal sportsbooks in your area.
🏆 Final Four odds, expert picks & predictions
Here's a look at the latest odds for both of Saturday's Final Four matchups via BetMGM, along with our expert picks and predictions for the 2025 NCAA Tournament semifinals:
📈 Latest Final Four odds for Saturday
| Matchup | Spread | Moneyline | Total (O/U) |
|---|---|---|---|
| Auburn vs. Florida | Florida -2.5 (-110) | Florida -150 | O/U 159.5 |
| Duke vs. Houston | Duke -5.5 (-105) | Duke -275 | O/U 136.5 |
🏀 No. 1 Auburn vs. No. 1 Florida (6:09 PM ET)
Two months ago, Florida upset then-No. 1 ranked Auburn in a 90-81 shoot-out to hand the Tigers their first home defeat of the season and one of just two such losses all year.
The Gators have only fallen once since then - a five-point road loss at Georgia on Feb. 25 - and knocked off two top-10 teams by KenPom in the Sweet 16 and Elite Eight to reach this point. Meanwhile, Auburn hasn't looked right in over a month, and superstar big man Johni Broome is battling an injury that knocked him out of the Elite Eight.
All of that is baked into the latest March Madness odds, which have Florida favored by 2.5 points over its SEC rival. I don't think that line goes far enough given the recent form of these two teams and how it played out the last time they faced off. If the Tigers don't have an answer for red-hot guard Walter Clayton Jr., their season will end on Saturday night.
📊 Auburn vs. Florida odds
🔮 Auburn vs. Florida prediction & picks
✅ Florida -2.5 (-110 via Caesars)
✅ Florida ML (-146 via FanDuel)
Caesars is a 21+ product
🏀 No. 1 Duke vs. No. 1 Houston (8:49 PM ET)
Forget about Houston for a second: can anyone in the country beat this Duke team when its future NBA stars are all clicking like they have been in this tournament?
Cooper Flagg might be the best player college basketball has seen in a decade (or longer), and he's surrounded by four other stars who all rank among the best players in March Madness. It's no wonder the Blue Devils boast the second-highest efficiency rating in the KenPom era (since 1997) after winning their first four NCAA Tournament games by 23.5 points on average.
Houston's top-ranked defense should pose a meaningful challenge to Jon Scheyer's group, but I have my doubts that this one will still be close by the final buzzer.
📊 Duke vs. Houston odds
🔮 Duke vs. Houston prediction & picks
✅ Duke -5 (-110 via Caesars)
✅ Duke ML (-255 via FanDuel)
🏆 NCAA Tournament national championship odds, expert picks & predictions
While we're still awaiting the exact matchup for the national championship, we can use the March Madness look-ahead odds to get a sense of what the betting lines might be for a hypothetical matchup between favorites Duke and Florida on Monday:
🏀 No. 1 Duke vs. No. 1 Florida (8:50 PM ET)
We can only hope and pray that this matchup comes to fruition ahead of what should be an all-time classic semifinals in San Antonio.
To be clear: Duke is the creme de la creme in this tournament, and I still think the Blue Devils can start preordering ladders and scissors for Monday night. But Florida was the hottest team coming into this tournament and has lived up to the billing behind Clayton, who has put on a scoring clinic in March to etch his name in tournament lore.
These are the two most talented rosters left in the field, and the Gators are the only group with the offensive firepower to hang with Duke for 40 minutes. But their defense doesn't quite feature the elite length that you'd hope for to hold down the NBA-lite team on the other side.
It's worth tuning in on Monday because you never know what might happen under the bright lights of the NCAA Tournament. But it's worth wagering on Duke while you're at it.
📊 Duke vs. Florida odds
Here are the latest hypothetical odds for Duke vs. Florida courtesy of FanDuel:
| Market | Duke | Florida |
|---|---|---|
| Spread | -4.5 (-120) | +4.5 (-102) |
| Moneyline | -205 | +168 |
| Total | Over 158.5 (-105) | Under 158.5 (-115) |
🔮 Duke vs. Florida prediction & picks
✅ Duke -4.5 (-120 via FanDuel)
✅ Duke ML (-205 via FanDuel)
🆚 Final Four game predictions
- Auburn vs. Florida prediction
- Auburn vs. Florida player props
- Auburn vs. Florida parlay
- Duke vs. Houston prediction
- Duke vs. Houston player props
- Duke vs. Houston parlay
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👑 Best March Madness betting sites
Ready to place your March Madness bets? Check out the best March Madness betting promos from our best March Madness betting sites, as determined by our expert team at Sportsbook Review.
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