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Duke Blue Devils guard Cooper Flagg looks for an opening to pass during the second half against the Maine Black Bears as we look at our Duke vs. Arizona prediction.
Duke Blue Devils guard Cooper Flagg looks for an opening to pass during the second half against the Maine Black Bears. Photo by Zachary Taft/Imagn Images.

Our Duke vs. Arizona prediction should help to set the stage for the marquee college basketball matchup of the night.

No. 12 Duke (3-1) will travel to face No. 17 Arizona (2-1) at 10:30 p.m. ET on Friday inside McKale Center. The matchup is a sign that college basketball is trending in the right direction, as these two teams would have typically scheduled a tuneup game following recent losses.

Instead, college basketball fans are treated to a high-stakes clash between two hungry schools. Arizona is a slight favorite at home, but will Cooper Flagg and Co. earn a road win?

Flagg remains among the Wooden Award odds favorites.

Tonight's best Duke vs. Arizona picks

College basketball picks based on the odds from our best March Madness betting sites. Odds subject to change.

Duke to cover the spread: +1.5 ⭐⭐⭐

Best odds: -110 via BetMGM | Implied probability: 52.38%

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Duke might have lost to Kentucky in the Champions Classic, but there's an argument the Blue Devils are the most talented team in college basketball. It’s only a matter of time before it all clicks for them.

I’m not saying Duke is necessarily right after its 86-35 shellacking of Wofford, but this is the type of matchup in which the Blue Devils’ should flex their athleticism and talent.

Arizona wants to get into a track meet, as it ranks fourth in adjusted tempo. That’s why the total has climbed six points from the opening number. That bodes well for the Blue Devils, who rank 10th in adjusted offensive efficiency and have scored 86-plus points in three of their four games.

Bart Torvik projects a 78-76 victory for Duke on Friday, so I’ll take the +1.5 at BetMGM before it’s too late. This game will likely close as a pick 'em.

Duke vs. Arizona best bet

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Cooper Flagg to record Over 9.5 rebounds ⭐⭐⭐⭐

Best odds: +185 via DraftKings | Implied probability: 35.09%

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Our best sportsbooks haven't yet posted a rebounds total for Flagg, but I’d assume his line will be around 8.5. He’s averaging 9.5 rebounds per game this year.

I like taking the +185 price on Flagg to record double-digit rebounds via DraftKings’ alternate market. I project a little over nine boards, suggesting a fair price closer to even money on this prop.

Flagg has collected double-digit rebounds in two of his four contests this season. He recorded 11 rebounds in 32 minutes against Kentucky. I like Flagg’s chances of cashing this prop during an uptempo contest featuring more shots.

Live Duke vs. Arizona odds

See all of this week's college basketball odds and NCAAB scores.

Duke vs. Arizona opening odds

  • Spread: Duke +1.5 (-110) | Arizona -1.5 (-110)
  • Over/Under: Over 155.5 (-115) | Under 155.5 (-105)
  • Moneyline: Duke +104 | Arizona -118

Duke vs. Arizona game info

  • When: Friday, Nov. 22
  • Tipoff: 10:30 p.m. ET
  • Where: McKale Center (Tuscon)
  • How to watch: ESPN
  • Favorite: Arizona -1.5 (-110 via BetMGM)

College basketball betting odds pages

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