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Texas quarterback Quinn Ewers looks to pass against Kentucky. The Longhorns game against Texas A&M is the biggest game of our Week 14 college football predictions.
Texas quarterback Quinn Ewers looks to pass against Kentucky. Photo by Scott Wachter via Imagn Images.

In the final week of the regular season, our Week 14 college football predictions highlight the can't-miss matchups, including several of the biggest rivalries in the sport.

  • One win away from securing a spot in the Big Ten Championship, college football championship odds favorite Ohio State takes on hated rival Michigan
  • Colorado is desperate for a win to get a chance at the Big 12 Championship, with Heisman Trophy odds favorite Travis Hunter leading the Buffaloes against Oklahoma State
  • In arguably the most important game for the College Football Playoff odds, the Lone Star Showdown is finally back with the winner of Texas vs. Texas A&M going to the SEC Championship

Thanks to rivalry week coinciding with Thanksgiving, there's a plethora of AP Top 25 teams playing important games ahead of conference championship weekend next week.

College football picks & predictions Week 14

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Don't miss the rest of our Week 14 college football picks.

College football odds for Thursday

College football odds via DraftKings and subject to change. Follow the latest college football scores for line history and matchup info.

Memphis vs. Tulane odds

Prediction: Darian Mensah Over 1.5 passing touchdowns (-120 via bet365) ⭐⭐⭐⭐⭐

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Pick made by Matthew MacKay

  • When: Thursday, Nov. 28 (7:30 p.m. ET)
  • Where: Yulman Stadium (New Orleans, La.)
  • How to watch: ESPN
  • Moneyline: Memphis (+400) | Tulane (-535)
  • Spread: Memphis +14 (-110) | Tulane -14 (-110)
  • Total: 55.5 (-112/-108)

College football odds for Friday

Oregon State vs. Boise State odds

  • When: Friday, Nov. 29 (noon ET)
  • Where: Albertsons Stadium (Boise, Idaho)
  • How to watch: FOX
  • Moneyline: Oregon State (+750) | Boise State (-1200)
  • Spread: Oregon State +20.5 (-112) | Boise State -20.5 (-108)
  • Total: 56.5 (-110/-110)

Oklahoma State vs. Colorado odds

  • When: Friday, Nov. 29 (noon ET)
  • Where: Folsom Field (Boulder, Colo.)
  • How to watch: ABC
  • Moneyline: Oklahoma State (+600) | Colorado (-900)
  • Spread: Oklahoma State +17 (-112) | Colorado -17 (-108)
  • Total: 65.5 (-108/-112)

Mississippi State vs. Ole Miss odds

  • When: Friday, Nov. 29 (3:30 p.m. ET)
  • Where: Vaught-Hemingway Stadium (Oxford, Miss.)
  • How to watch: ABC
  • Moneyline: Mississippi State (+1500) | Ole Miss (-3600)
  • Spread: Mississippi State +26 (-110) | Ole Miss -26 (-110)
  • Total: 61.5 (-112/-108)

Georgia Tech vs. Georgia odds

  • When: Friday, Nov. 29 (7:30 p.m. ET)
  • Where: Sanford Stadium (Athens, Ga.)
  • How to watch: ABC
  • Moneyline: Georgia Tech (+700) | Georgia (-1100)
  • Spread: Georgia Tech +19.5 (-110) | Georgia -19.5 (-110)
  • Total: 54 (-110/-110)

College football odds for Saturday

Michigan vs. Ohio State odds

  • When: Saturday, Nov. 30 (noon ET)
  • Where: Ohio Stadium (Columbus, Ohio)
  • How to watch: FOX
  • Moneyline: Michigan (+1100) | Ohio State (-2100)
  • Spread: Michigan +21 (-112) | Ohio State -21 (-108)
  • Total: 43 (-110/-110)

Notre Dame vs. USC odds

  • When: Saturday, Nov. 30 (3:30 p.m. ET)
  • Where: Los Angeles Memorial Coliseum (Los Angeles)
  • How to watch: CBS
  • Moneyline: Notre Dame (-265) | USC (+215)
  • Spread: Notre Dame -7.5 (-108) | USC +7.5 (-112)
  • Total: 51.5 (-105/-115)

Auburn vs. Alabama odds

  • When: Saturday, Nov. 30 (3:30 p.m. ET)
  • Where: Bryant-Denny Stadium (Tuscaloosa, Ala.)
  • How to watch: ABC
  • Moneyline: Auburn (+340) | Alabama (-440)
  • Spread: Auburn +11.5 (-110) | Alabama -11.5 (-110)
  • Total: 52 (-112/-108)

Oklahoma vs. LSU odds

  • When: Saturday, Nov. 30 (7 p.m. ET)
  • Where: Tiger Stadium (Baton Rouge, La.)
  • How to watch: ESPN
  • Moneyline: Oklahoma (+185) | LSU (-225)
  • Spread: Oklahoma +6.5 (-112) | LSU -6.5 (-108)
  • Total: 47 (-112/-108)

Texas vs. Texas A&M odds

  • When: Saturday, Nov. 30 (7:30 p.m. ET)
  • Where: Kyle Field (College Station, Texas)
  • How to watch: ABC
  • Moneyline: Texas (-230) | Texas A&M (+190)
  • Spread: Texas -6 (-108) | Texas A&M +6 (-112)
  • Total: 48.5 (-110/-110)

College football picks roundup: Week 14

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